Phillip B Hylemon Selected Research

Protease Inhibitors (Protease Inhibitor)

1/2004	Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7alpha-hydroxylase mRNA levels.
11/2002	Suppression of cholesterol 7alpha-hydroxylase transcription and bile acid synthesis by an alpha1-antitrypsin peptide via interaction with alpha1-fetoprotein transcription factor.

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Phillip B Hylemon Research Topics

Disease

26	Fibrosis (Cirrhosis) 02/2024 - 01/2013
22	Inflammation (Inflammations) 02/2024 - 11/2002
10	Non-alcoholic Fatty Liver Disease 11/2023 - 06/2008
7	Dysbiosis 02/2024 - 01/2015
7	Liver Diseases (Liver Disease) 01/2024 - 01/2015
7	Liver Cirrhosis (Hepatic Cirrhosis) 01/2023 - 01/2017
6	Neoplasms (Cancer) 03/2023 - 01/2008
6	Cholangiocarcinoma 03/2023 - 08/2014
6	Cholestasis 01/2023 - 09/2014
5	Infections 12/2019 - 01/2005
4	Disease Progression 10/2021 - 01/2015
4	Fistula 04/2015 - 04/2002
4	HIV Infections (HIV Infection) 01/2014 - 02/2010
4	Atherosclerosis 07/2009 - 11/2002
4	Colonic Neoplasms (Colon Cancer) 03/2006 - 05/2003
3	Neuroinflammatory Diseases 01/2021 - 10/2016
3	Endotoxemia 08/2016 - 01/2013
3	Hepatic Encephalopathy 08/2016 - 01/2013
3	Hyperlipidemias (Hyperlipidemia) 02/2015 - 01/2004
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2013 - 09/2005
2	Hepatocellular Carcinoma (Hepatoma) 03/2023 - 08/2014
2	Liver Neoplasms (Liver Cancer) 03/2023 - 05/2014
2	Neoplasm Metastasis (Metastasis) 03/2023 - 11/2012
2	Digestive System Diseases 01/2023 - 01/2016
2	Insulin Resistance 12/2020 - 08/2014
2	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2019 - 01/2018
2	Hyperammonemia 01/2016 - 09/2015
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2015 - 11/2007
2	End Stage Liver Disease 09/2012 - 01/2012
2	Dyslipidemias (Dyslipidemia) 08/2010 - 02/2010
1	Brain Diseases (Brain Disorder) 02/2024
1	Encephalitis (Encephalitis, Rasmussen) 02/2024
1	Sarcopenia 02/2024
1	Alcoholism (Alcohol Abuse) 10/2022
1	Fatty Liver 12/2021
1	Acute Liver Failure (Fulminant Hepatic Failure) 11/2021
1	Diabetes Mellitus 01/2021
1	Metabolic Diseases (Metabolic Disease) 01/2021
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 11/2020
1	Sclerosing Cholangitis 11/2020
1	Biliary Atresia 11/2019

Drug/Important Bio-Agent (IBA)

28	Bile Acids and Salts (Bile Acids)IBA 01/2024 - 04/2002
9	HIV Protease InhibitorsIBA 01/2014 - 09/2005
8	Rifaximin (L 105)FDA Link 01/2021 - 01/2012
7	Long Noncoding RNAIBA 03/2023 - 10/2019
6	BerberineIBA 01/2024 - 02/2010
6	LipidsIBA 11/2023 - 09/2005
5	AmmoniaIBA 02/2024 - 08/2016
5	CholesterolIBA 12/2021 - 11/2002
5	Sphingosine-1-Phosphate ReceptorsIBA 12/2021 - 09/2014
5	Taurocholic Acid (Sodium Taurocholate)IBA 01/2018 - 08/2010
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2023 - 01/2015
4	Messenger RNA (mRNA)IBA 01/2019 - 04/2002
3	CytokinesIBA 02/2024 - 10/2015
3	RNA (Ribonucleic Acid)IBA 03/2023 - 01/2018
3	Fatty Acids (Saturated Fatty Acids)IBA 10/2022 - 11/2012
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2006
3	Interleukin-6 (Interleukin 6)IBA 12/2019 - 09/2012
3	Lactulose (Duphalac)FDA LinkGeneric 10/2018 - 01/2012
3	Small Interfering RNA (siRNA)IBA 01/2017 - 01/2017
3	Glutamine (L-Glutamine)FDA Link 10/2016 - 01/2016
2	isoquinolineIBA 01/2024 - 01/2020
2	AlkaloidsIBA 01/2024 - 01/2020
2	Glucose (Dextrose)FDA LinkGeneric 11/2023 - 01/2021
2	CalciumIBA 11/2023 - 01/2021
2	AMP-Activated Protein KinasesIBA 01/2021 - 01/2017
2	Insulin (Novolin)FDA Link 01/2021 - 05/2020
2	gamma-Aminobutyric Acid (GABA)IBA 01/2020 - 01/2019
2	Nonesterified Fatty Acids (NEFA)IBA 01/2020 - 06/2008
2	sphingosine kinaseIBA 01/2019 - 04/2015
2	Proton Pump InhibitorsIBA 01/2018 - 11/2014
2	Omeprazole (Prilosec)FDA LinkGeneric 01/2018 - 11/2014
2	Estrogens (Estrogen)FDA Link 01/2017 - 01/2017
2	Cadherins (E-Cadherin)IBA 01/2017 - 08/2016
2	GlutaminaseIBA 10/2016 - 08/2016
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2004 - 11/2002
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 02/2024
1	rifamycin SVIBA 02/2024
1	MicroRNAs (MicroRNA)IBA 03/2023
1	Vancomycin FDA LinkGeneric 01/2023
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 10/2022
1	FatsIBA 12/2021
1	High Fructose Corn SyrupIBA 12/2021
1	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2021
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2021
1	FructoseIBA 01/2021
1	UreaseIBA 01/2021
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	Biological FactorsIBA 12/2020
1	steroidogenic acute regulatory proteinIBA 12/2020
1	OxysterolsIBA 12/2020
1	CarbohydratesIBA 05/2020
1	16S Ribosomal RNAIBA 01/2020
1	lipopolysaccharide-binding proteinIBA 12/2019

Therapy/Procedure

5	Fecal Microbiota Transplantation 10/2022 - 09/2015
5	Therapeutics 10/2021 - 11/2014
5	Highly Active Antiretroviral Therapy (HAART) 01/2014 - 09/2005
2	Ligation 11/2020 - 01/2018
1	Vagotomy 01/2021